The Neurodeath Associated Unit (Spanish National Research Council / University of Castilla-La Mancha), belonging to the Institute of Molecular Nanoscience (INAMOL) of the University of Castilla-La Mancha (UCLM), has published an article in the journal Biomacromolecules (https://doi.org/10.1021/acs.biomac.5c00171), which identifies the properties that nanoparticles, in this case dendrimers based on phosphorus chemistry, must have in order to effectively fix siRNA. SiRNA is a molecule made up of genetic material capable of markedly and specifically reducing the levels of the proteins against which it has been designed, which makes it a new therapeutic molecule that has already reached the clinical environment for the treatment of several diseases.
This work has been carried out in collaboration with research groups from the CNRS (the equivalent in France to the Spanish National Research Council), the company Sanofi R&D and the Department of Inorganic, Organic and Biochemical Chemistry of the UCLM. This work is part of the Biotechnology Applied to Health project of the NextGeneration Complementary Plans of the European Union. It should be noted that groups from two different Complementary Plans, Biology Applied to Health and Materials, have collaborated in this work, this collaboration arising from the joint meeting between both plans that was held on June 13 and 14, 2024 in Toledo.
