The UCLM-CSIC “Neurodeath” Associated

Universidad de Castilla-La Mancha (Albacete).
IP – Valentín Ceña.

The UCLM-CSIC “Neurodeath” Associated Unit is located at the Faculty of Medicine of Albacete. It is directed by Prof. Valentín Ceña and is currently made up of two senior scientists, two postdoctoral fellows, two doctoral students, a technician and an assistant.

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The group’s main line of research focuses on the use of nanoparticles and siRNA to reduce the levels of proteins involved in the pathophysiology of neurodegenerative diseases and cancer both in vitro and in vivo More specifically, the group is interested in developing nanoparticles that can transport siRNA into glioblastoma and prostate cancer cells to enhance the therapeutic effect of anti-cancer drugs.

The group has identified several nanoparticles that are capable of efficiently transporting siRNA into tumor cells and simultaneously reducing the cellular levels of up to three proteins involved in signaling survival and proliferation pathways in both glioblastoma and cancer cells. prostate. Furthermore, it has been shown that some of these nanoparticles are capable of transporting labeled siRNA to the brain. These particles do not modify any biochemical parameters in the serum of the animals.