The Laboratory Medicine research group is made up of professionals specialising in Clinical Analysis, Clinical Biochemistry and Immunology, belonging to the Clinical Analysis and Clinical Biochemistry Services of the general university hospitals of Albacete, Toledo and Villarrobledo, as well as the Spanish Research Group on Biological Rhythms and Laboratory Medicine.
The main line of research.
The group’s research activity focuses on the use of nanoparticles and siRNA to decrease the levels of proteins involved in the pathophysiology of neurodegenerative diseases and cancer, both in vitro and in vivo.
More specifically, the group is interested in developing nanoparticles that can transport siRNA into glioblastoma and prostate cancer cells, to enhance the therapeutic effect of anticancer drugs.
Highlights.
The team has identified several nanoparticles that are capable of efficiently transporting siRNA into tumor cells and simultaneously reducing the cellular levels of up to three proteins involved in signaling survival and proliferation pathways in both glioblastoma and prostate cancer cells.
In addition, some of these nanoparticles have been shown to be able to transport labeled siRNA.