Professor Valentín Ceña of the University of Castilla-La Mancha – (Faculty of Medicine-Pharmacology (AB), Neurodeath Associated Unit UCLM-CSIC), gave a lecture on March 20 at the Royal National Academy of Pharmacy (RANF), entitled: “Nanoparticles and aptamers as siRNA transporters: a new path towards personalized medicine“.
During his speech, he presented the progress made in the development of the project New therapeutic approaches for glioblastoma, which is part of Line of Action 5: Development of nanodrugs, biodistribution, toxicity and therapeutic actions in pathology models within the Complementary Plan for Biotechnology Applied to Health.
In this conference, he outlined the different steps that have been taken to test the effectiveness of a nanoparticle based on dihydropyridines as a vehicle to transport, in a very efficient way, siRNA against 3 proteins involved in the proliferation and survival of glioblastoma cells such as p42-MAPK, Rheb and MGMT.
Specific siRNAs efficiently reduced levels of the target proteins by about 90% in both commercial glioblastoma cell lines and patient-derived cell lines and cells isolated from organoids generated from patient tumors.
He also showed that the nanoparticles used in this project are distributed in the central nervous system and are capable of transporting siRNA to this system, which represents a significant advance towards more precise and personalized therapies.
The conference was presented by professor Juan Tamargo, president of Section 4 of the Royal National Academy of Pharmacy, and was attended by various academics, among whom were the presidency of the Institution, represented by Professor Antonio Doadrio.
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